This course provides a hands-on comprehensive study of Cloud concepts and capabilities across the various Cloud service models including Infrastructure as a Service (IaaS), Platform as a Service (PaaS), and Software as a Service (SaaS). IaaS topics start with a detailed study the evolution of infrastructure migration approaches from VMWare/Xen/KVM virtualization, to adaptive virtualization, and Cloud Computing / on-demand resources provisioning. Mainstream Cloud infrastructure services and related vendor solutions are also covered in detail. PaaS topics cover a broad range of Cloud vendor platforms including AWS, Google App Engine, Microsoft Azure and others as well as a detailed study of related platform services such as storage services that leverage Google Storage, Amazon S3, Amazon Dynamo, or other services meant to provide Cloud resources management and monitoring capabilities. The SaaS and PaaS topics covered in the course will familiarize students with the use of vendor-maintained applications and processes available on the Cloud on a metered on-demand basis in multi-tenant environments. The course also covers the Cloud security model and associated challenges and delves into the implementation and support of High Performance Computing and Big Data support capabilities on the Cloud.